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¿Àº¹ÀÚ ( Oh Pok-Ja ) - »ïÀ°´ëÇб³ °£È£Çаú
ÀåÀº¼ö ( Jang Eun-Su ) - »ïÀ°´ëÇб³ ´ëÇпø °£È£Çаú
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Abstract
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Purpose: This study was done to evaluate the effects of psychosocial interventions on cortisol and immune response in adult patients with cancer.
Methods: MEDLINE via PubMed, Cochrane Library CENTRAL, EMBASE, CINAHL and domestic electronic databases were searched. Twenty controlled trials (11 randomized and 9 non-randomized trials) met the inclusion criteria with a total of 862 participants. Methodological quality was assessed using the Cochrane¡¯s Risk of Bias for randomized studies and the Risk of Bias Assessment tool for non randomized studies. Data were analyzed using the RevMan 5.2.11 program of Cochrane library.
Results: Overall, study quality was moderate to high. The weighted average effect size across studies was -0.32 (95% CI [-0.56, -0.07], p=.010, I2=45%) for cortisol concentration, -0.62 (95%CI [-0.96,-0.29], p<.001, I2=0%) for T lymphocyte (CD3) and -0.45 (95%CI [-0.74, -0.16], p=.003, I2=0%) for Th lymphocyte (CD4) numbers. Psychosocial interventions were not effective for Tc lymphocyte (CD4), NK cell, monocyte, and cytokine response.
Conclusion: Although these results provide only small evidence of successful immune modulation, they support the conclusion that psychosocial interventions can assist cancer patients in reducing emotional distress and improving immune response.
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KeyWords
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Neoplasm, Cortisol, Immune, Intervention studies, Meta-analysis
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